Abstract

STEFANO, Paola C. et al. Microsporum gypseum dermatophytosis in a child with primary immunodeficiency. Arch. argent. pediatr. [online]. 2022, vol.120, n.3, pp.13-13.  Epub June 01, 2022. ISSN 0325-0075.  http://dx.doi.org/10.5546/aap.2022.e128.

Microsporum gypseum is a geophilic fungus that can cause inflammatory skin lesions in heathy people. More extensive lesions have been described in immunocompromised patients. We present a patient with extensive dermatophytosis, which mycological examination led the identification of Candida sp, Epidermophyton Floccosum and Trichophyton tonsurans and showed poor response to treatment with griseofulvina and itraconazol at usual doses. When skin biopsy was performed, it had positive culture for M. gypseum. Due to the extension and poor response to treatment, immunological assessment was performed and it showed a defect of STAT1 with gain of function (STAT 1-GOF). Patients with primary immunodeficiency are susceptible to fungal infections, especially Candida but also virus and bacteria, although to a lesser extent. The patient received long-term treatment with systemic imidazole antifungal recovering for the lesions.

Keywords : pediatric; Microsporum gypseum; STAT1 transcription factor.

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