Abstract

COSTANZO, Pablo  and  SALERNI, Helena. Hypovitaminosis D: non-classical effects. Rev. argent. endocrinol. metab. [online]. 2009, vol.46, n.1, pp.3-23. ISSN 1851-3034.

Vitamin D deficiency is prevalent worlwide and affects people of all ages. Calcium intestinal absorption regulation along with calcium, phosphorous and bone homeostasis are most important vitamin D roles. Raquitism is commonly associated with vitamin D deficiency in children. Vitamin D deficiency related diseases varies from osteomalacia to hyperparathyroidism (with bone loss and increased risks of falls and fractures) in adults. Besides this well known actions, vitamin D regulates the growth and differentiation of smooth muscle cells, regulates the renin-angiotensin-aldosterone system, promotes the release of insulin, regulates cell growth and stimulates the differentiation of monocytes-macrophages, antigen presenting cells, dendritic cells and lymphocytes. In recent years, many authors have linked to hypovitaminosis D with autoimmune diseases, Type2 diabetes mellitus, cardiovascular disease and cancer among others diseases. These not traditionally vitamin D deficiency associated conditions are going to be subjects for this review.

Keywords : Vitamina D; Hipovitaminosis D; Osteomalacia; Hiperparatiroidismo; Vitamin D; Hypovitaminosis D; Osteomalacia; Hyperparathyroidism.

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