Abstract

POTILINSKI, María Constanza et al. Possible senescence associated change in the predominant α-Na⁺/K⁺ ATP-ase isoform in the renal cortex of the rat. Medicina (B. Aires) [online]. 2016, vol.76, n.4, pp.204-207. ISSN 0025-7680.

With aging the kidney exhibits progressive deterioration, with a decrease in renal function. Most of the filtered Na+ is actively reabsorbed in the proximal tubules through different transporters located in apical membrane. This process is possible because basolateral Na+/K+-ATP-ase generates electrochemical conditions necessary for energetically favorable Na+ transport. The α-subunit is the catalytic domain of Na+/K+-ATP-ase. There are three isoforms of the α/subunit present in rat kidney. The present study was undertaken to examine the expression pattern of rat α-Na+/K+-ATP-ase during senescence. We tested the impact of aging on mRNA expression of α-Na+/K+-ATP-ase in cortex and medulla of aged Wistar rats. We observed a significant expression decrease in mRNA levels and a possible change of isoform in the cortex of aged animals. These expression changes observed for αsubunit could be contributing to affect the renal function in conditions of water and salt stress.

Keywords : Aging; Kidney; Sodium-potassium-exchanging ATPase.

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