Abstract

RODRIGUEZ ARIAS, Edwin A. et al. Nicolau syndrome. Medicina (B. Aires) [online]. 2023, vol.83, n.1, pp.145-148. ISSN 0025-7680.

Nicolau syndrome is a rare complication of the parenteral application of various drugs. It is char acterized by the appearance of pain, followed by edema, erythema, and then a necrotic plaque. We present the case of a 31-year-old male with this syndrome, after the application of intramuscular benzathine penicillin. The diagnosis was supported by the biopsy. He received treatment with enoxaparin and cilostazol with subsequent improvement.

Keywords : Nicolau syndrome; Drug skin embolism; Livedoid dermatitis; Penicillin; Adverse effect.

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