Abstract

IDIAZABAL, María Angeles; PALAU, Montserrat; FERNANDEZ, Elena  and  FIERRO, Galit. Neurophysiological studies in neurodevelopmental disorders: event related potentials. Medicina (B. Aires) [online]. 2023, vol.83, suppl.2, pp.12-16. ISSN 0025-7680.

Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are neurodevel opmental disorders whose diagnosis is clinical and with great variability in clinical presentation. The possibility of identifying and validating biomarkers in these neurodevelopmental disorders would help not only in their diagnosis, but also when implementing personalized treatments and monitori ng the response to treatment. Neurophysiologi cal examinations such as event related potentials (ERP) are one of the most widely used tools to objectively assess cognitive functions with high temporal resolution and provide information on the underlying neurobiological mechanisms, making them a very useful tool to assess cognitive alterations associated with neurodevelopmental disorders. Different components of the ERP have been used for the study of neurodevelopmental disorders, such as the P300, N400 component or the N170 component as a biomarker of social dysfunction in ASD. We review the main components of ERP that have been studied as complementary tools in the diagnosis and monitoring of treatments in neurodevelopmental disorders.

Keywords : Autism spectrum disorder; Attention deficit hyperactivity disorder; Biomarkers; Event related potentials.

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