Abstract

MILANESIO, Martín et al. Hodgkin’s lymphoma: sensitive and autonomic neuropa thy as a paraneoplastic manifestation. Medicina (B. Aires) [online]. 2023, vol.83, n.3, pp.484-488. ISSN 0025-7680.

Hodgkin lymphoma (HL) comprises a heterogeneous group of lymphoid neoplasms whose origin lies in B lym phocytes. The neurological manifestations of this pathol ogy are infrequent, and may arise from direct invasion of neoplastic cells to the nervous system, or indirectly, through paraneoplastic syndromes or as a complication of treatment. Among the neurological paraneoplastic syndromes that affect patients with HL, paraneoplastic cerebellar degeneration is the most common. Other few cases include limbic encephalitis, sensory, motor, and autonomic neuronopathy. These syndromes can be the initial manifestation of neoplastic disease, and the lack of information regarding this association can lead to a delay in diagnosis and consequently in the initiation of therapy worsening the prognosis. We report the case of a woman with HL who presented sensory and autonomic neuronopathy at the onset of her disease as paraneo plastic neurological manifestations. After the initiation of the specific treatment for the lymphoma, the autonomic neuronopathy had almost complete resolution, unlike the sensory neuronopathy, which showed limited recovery.

Keywords : Hodgkin disease; Paraneoplastic syn dromes; Nervous system paraneoplastic syndromes; Paraneoplastic polyneuropathy.

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