Abstract

RAMIREZ STIEBEN, Luis A.. Subcutaneous administration of levothyroxine in refrac tory hypothyroidism. Medicina (B. Aires) [online]. 2023, vol.83, n.4, pp.622-625. ISSN 0025-7680.

Hypothyroidism can usually be treated effectively with oral levothyroxine (LT-4) supplementation. However, hypothyroidism refractory to treatment with LT-4 is a common clinical condition. Causes include poor com pliance, interactions with food or other medications, and gastrointestinal diseases, such as inflammatory bowel disease and short bowel syndromes. Increasing the oral dose of LT-4 is not always effective in these scenarios. Therefore, other routes of administration may be neces sary. In this report, we evaluate alternative treatment modalities for refractory hypothyroidism and present two patients with intestinal malabsorption successfully treated by subcutaneous administration of LT-4.

Keywords : Hypothyroidism; Levothyroxine; Malab sorption syndromes; Thyroid neoplasms.

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