Abstract

VAZQUEZ, Nicolás M; CACERES GUIDO, Paulo; FIORILLI, Graciela  and  MORENO, Silvia. Emerging mupirocin resistance in methiciüin-resistant Staphylococcus aureus isolates at a tertiary care children's hospital in Argentina. Arch. argent. pediatr. [online]. 2019, vol.117, n.1, pp.48-51. ISSN 0325-0075.  http://dx.doi.org/10.5546/aap.2019.48.

In Latin America, few studies have been done in mupirocin resistance and biofilm formation in methicillin-resistant Staphylococcus aureus (MRSA). This study investigated mupirocin-resistance in MRSA isolates from pediatric patients with bacteremia and their ability to form biofilm. Antibiotic resistance was analyzed with the Kirby-Bauer test and the broth microdilution method. Bacterial biofilm formation was measured using the crystal violet assay. Among MRSA isolates, 2.3 % (5/217) exhibited a high level of mupirocin-resistance with a minimum inhibitory concentration of > 512 μg/mL, in addition to cross-resistance with clindamycin, erythromycin, gentamicin, and ciprofloxacin. Remarkably, biofilm formation in such isolates was moderate to high. This is the first report published in Argentina on clinical isolates of mupirocin-resistant MRSA and it is critical for following its evolution over time at a local level and in the Latin American region.

Keywords : Staphylococcus aureus; Resistance to drugs; Mupirocin; Biofilm; Paediatrics.

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