Abstract

SANCHEZ-RODRIGUEZ, Martha A.; RETANA-UGALDE, Raquel; RUIZ-RAMOS, Mirna  and  MENDOZA-NUNEZ, Víctor Manuel. Antioxidant capacity in relationship to serum lipid peroxides levels in healthy elderly of Mexico City. Acta bioquím. clín. latinoam. [online]. 2004, vol.38, n.2, pp.193-198. ISSN 0325-2957.

The aging is one of the factors that cause decrease in the antioxidant capacity. Likewise, it has been proposed that subjects exposed permanently to air pollution develop deficient antioxidant capacity to oxidative stress (OxS). This study aimed to analyze the antioxidant capacity against elevated lipid peroxides in healthy elderly of Mexico City. 105 adults (44 ± 10.8 years) and 126 elderly subjects were studied (68 ± 7.1 years); residents of Mexico City (clinically healthy, non-smokers, non-vitamin supplement takers) who had lived in the city for >10 years. Plasma lipoperoxides (LPO), total antioxidant status (TAS), the activity of red blood cells superoxide dismutase (SOD), and plasma glutathione peroxidase (GPx), were studied in all subjects. LPO levels were found significantly higher (p < 0.05) in the elderly subjects in comparison with the adults; in addition, TAS and GPx were higher in adults than among the elderly people (p < 0.0001). Nevertheless, SOD was similar in both groups (p = 0.346). These findings reveal that the elderly residents of Mexico City have TAS and GPx lower than adults, and similar SD activity, probably due to the fact that these antioxidants are neutralizing the higher LPO levels of elderly people. Therefore, this mechanism could be considered as an efficient antioxidant capacity in the elderly, as response to high LPO levels, since the health status, mortality prevalence and life span life of the older people of Mexico City are similar or better than other cities of Mexican Republic.

Keywords : Adaptation to oxidative stress; Total antioxidant status; Elderly people; Pollution; Superoxide dismutase; Glutathione peroxidase.

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