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Acta bioquímica clínica latinoamericana
Print version ISSN 0325-2957On-line version ISSN 1851-6114
Abstract
POLINI, Nélida Nélida; MASSHEIMER, Virginia Laura and SELLES, Juana. Effects of progesterone on platelet aggregation and rat aorta eicosanoid production. Acta bioquím. clín. latinoam. [online]. 2004, vol.38, n.3, pp.281-287. ISSN 0325-2957.
Using rat aortic tissue, the non genomic action of progesterone (Pg) on nitric oxide (NO), prostacyclin (PGI2), and tromboxane (Tx) synthesis and its relationship with platelet aggregation were studied. Treatment of female rat aortic rings (RAS) with Pg induced a dose-dependent inhibition of platelet aggregation (IPA), which was partially abolished when RAS were treated in the presence of the specific NOS inhibitor N-nitro-L-arginine methyl ester (L-NAME). This observation would indicate that the inhibition of platelet aggregation (PA) resulted partially dependent on NOS stimulation by the hormone. Pg also produced a dose-dependent increase in PGI2 synthesis (42 at 182% respect to control), but no changes in Tx liberation by aorta was observed, at any concentration of Pg used. RAS preincubation with indomethacine, a COX inhibitor, partially reduced Pg antiaggregatory effect, suggesting that the inhibition of PA induced by hormone is also dependent on PGI2 generation. These results provide evidence that Pg modulates PA involving NO and PGI2 metabolic pathways.
Keywords : Platelet aggregation; Progesterone; Nitric oxide; Prostacyclin; Aterosclerosis; Ovarian hormones; Aorta.