Abstract

ESPONDABURU, Omar Raúl. Hipertriglyceridemia: influence on testing parameters which estimate the reverse cholesterol transport. Acta bioquím. clín. latinoam. [online]. 2006, vol.40, n.2, pp.165-172. ISSN 0325-2957.

The reverse cholesterol transport can be assessed by means of two parameters which indirectly quantify HDL: through the Apo AI, its majority protein, or by its cholesterol content (C-HDL). The aim of the project has been to analyse how the triglyceride rise (TG) modifies the Apo AI, C-HDL levels and the C-HDL/Apo AI relation. For this reason, 200 samples from patients from both sexes, aged between 20 and 60 years old, with cholesterol inferior to 240 mg/dL were analysed; out of them, half presented TG < 150 mg/dL and the rest corresponded to TG = 150-400 mg/dL. The TG were dosed by final stage colorimetry, C-HDL by direct enzymatic technique and Apo AI by immunoturbidimetric assay, using Roche Diagnostics reactives in a Hitachi 912 autoanalyzer. When analysing the samples' average Apo AI, C-HDL and C-HDL/Apo AI, inferior values were found for the TG range 150-400 mg/dL: a 5.15%, 20.34% and 12.28% respectively, being these differences significative for a 0.05 level. The correlation between C-HDL and Apo AI was good: r = 0.869 (P < 0.0001) with a line regression C-HDL = 0.55 Apo AI - 15.8 for TG < 150 mg/dL; and r = 0.862 (P < 0.0001) with a straight line C-HDL = 0.48 Apo AI - 15.1 for samples with the TG range 150-400 mg/dL; resulting a decrease in the C-HDL in the hypertriglyceridemic samples of: 0.07 Apo AI - 0.7. The C-HDL/Apo AI vs. TG graphic has shown a decrease in the C-HDL/Apo AI relation over the TG = 150 mg/dL, showing the presence of HDL low in cholesterol, so that C-HDL/Apo AI quotient makes up a good index of atherogenic risk associated to the efficiency of reverse cholesterol transport.

Keywords : hypertriglyceridemia; reverse cholesterol transport; apolipoprotein AI; high-density lipoprotein cholesterol; high-density lipoprotein cholesterol/apolipoprotein AI relation.

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