Abstract

GONZALEZ RIZO, Aileen et al. Beta-lactams susceptibility in Pseudomonas aeruginosa strains. Acta bioquím. clín. latinoam. [online]. 2007, vol.41, n.1, pp.63-66. ISSN 0325-2957.

Repetitive or chronic respiratory infections are common in cystic fibrosis patients, usually due to Pseudomonas aeruginosa. The recommended therapy is the combination of one aminoglycoside with a beta-lactam antibiotic. For this reason, the susceptibility of 54 Pseudomonas aeruginosa isolated obtained from the respiratory tract of cystic fibrosis patients to four beta-lactams was analysed. The study was performed by broth microdilution. Ceftazidime was the most active agent against Pseudomonas aeruginosa (85% of the total strains being susceptible).. Eighty three percent of the strains were inhibited by azlocillin and 37% by carbenicillin. Only 20% of all studied strains were susceptible to cefotaxime.

Keywords : Pseudomonas aeruginosa; cystic fibrosis; beta-lactams; in vitro susceptibility.

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