Abstract

LARREGINA, Andrea Elena et al. Reference intervals of serum b₂ microglobulin using two different immunoassays. Acta bioquím. clín. latinoam. [online]. 2009, vol.43, n.1, pp.27-30. ISSN 0325-2957.

The creation of a reference interval is important for the accurate diagnosis and prognosis on the local population. The aims of this study were to determine and verify the reference interval of serum b₂ microglobulin in Bahia Blanca. Two different immunoenzymatic assays were used simultaneously. The reference population was taken among volunteer blood donors who donated at the Hematology and Hemotheraphy Unit of the Hospital Municipal de Agudos "Dr. Leónidas Lucero", and Biochemistry students from the Universidad Nacional del Sur. Preanalytical alterations were ruled out using a questionnaire, and afterwards, venous blood samples were obtained. The calculated reference intervals were 0.78 to 1.47 mg/L and 1.18 to 2.36 mg/L for each method respectively. In the first case, it disagreed with that reported by the manufacturer. None of the assays was comparable, neither in accuracy nor in precision. This study shows that each measurement system should be informed with its corresponding reference interval.

Keywords : b₂ microglobulin; Reference intervals.

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