Abstract

DENZOIN VULCANO, Laura Andrea; SORACI, Alejandro Luis  and  TAPIA, Maria Ofelia. Glutathione homeostasis. Acta bioquím. clín. latinoam. [online]. 2013, vol.47, n.3. ISSN 0325-2957.

Glutathione is a unique molecule that participates in key cellular homeostasis, having a central role in defense against oxidative damage. GSH (L-g-glutamyl-L-cysteinyl-glycine) is a water soluble tripeptide composed of amino acid glutamic acid, cysteine and glycine. GSH is present in every cell cytoplasm. The oxidized form of the molecule, GSSG, is found primarily in extracellular form. GSH and GSSG concentrations and their molar ratio are indicators of cell function and its alteration is associated with several disease processes in humans and in companion animals. This review focuses on important aspects of homeostasis, major biological functions and available analytical methodologies for the analysis of GSH in blood and plasma.

Keywords : glutathione; oxidized glutathione; oxidative stress; g -glutamyl cycle.

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