Abstract

CORTES, Adrián; CORAL, Jonathan  and  BENITEZ BENITEZ, Ricardo. Identification of patterns for peptide-vaccines in universal capacity coupling HLA-II molecules. Acta bioquím. clín. latinoam. [online]. 2013, vol.47, n.3. ISSN 0325-2957.

Starting from the multiple alignment of human protein sequences obtained from the NCBI database (National Center of Biotechnology Information) and subsequent three-dimensional spatial analysis, the existence of a pattern of universal coupling to peptides presented by MHC molecules HLA-II (DR, DP and DQ) was established, being a basis for the design of protein vaccines. These spatial patterns were clearly exhibited by highly conserved residues of the three kinds of HLA-II molecules. The application of this new finding made it possible to design peptides with better Peptide -HLA-II coupling values than those generated by the universal coupling peptide called CLIP (class II-associated invariant chain peptide).

Keywords : multiple alignment; Major Histocompatibility Complex Class II; peptide invariant chain associated with Major Histocompatibility Complex Class II; human leukocyte antigen-type II; vaccine design.

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