Abstract

OSTA, Viviana; SEGURA, Celia; TISSERA, Gladys  and  AYUSO, Claudia. Study of efficiency and sensitivity of alarms of two hematology analyzers in a pediatric hospital. Acta bioquím. clín. latinoam. [online]. 2014, vol.48, n.1. ISSN 0325-2957.

The goal of the hematology laboratory is to improve workflow efficiency by optimizing instrument results and flagging sensitivity with its daily manual blood smears requirements. Two hematology analyzers (Coulter LH750 and CEL-DYN Ruby Abbott) were evaluated to determine analytical performance and efficiency in daily work at the Central Laboratory of a Pediatric Hospital. Microscopic revision was considered the reference method. A total of 178 pathological blood samples randomly selected from ambulatory and in-patients were analyzed in both analyzers. An excellent correlation between both instruments for leukocytes, erythrocytes, hemoglobin, MCV and platelet count was observed; also close agreement of results between manual differential and automated count. The efficiency of alarms triggered by the automated hematology analyzer was similar. Total efficiency of Cell-Dyn Ruby was 77% and 71.3% in the LH750. The false negative rate was 3.4% and 4.0% for the LH750 and Ruby respectively. The false positive rate was 17% for both instruments. It can be concluded that the two analyzers tested have a comparable analytical performance and each clinical laboratory must consider the characteristics of their population in order to establish critical and systematic criteria for manual microscopic review.

Keywords : hematology analyzers; flags; efficiency; microscopic review.

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