Abstract

CONIGLIO, Raúl Ignacio. Relationship between central obesity and metabolic syndrome components. Acta bioquím. clín. latinoam. [online]. 2014, vol.48, n.2, pp.191-201. ISSN 0325-2957.

The prevalence of obesity is increasing in Argentina and the world and this is associated with T2DM and CVD. Abdominal or central body adipose tissue behave secreting cytokines and free fatty acids that interfere with insulin signal transduction and promote insulin resistance generating diabetogenic, prothrombotic and chronic low-grade inflammation. These metabolic changes over time lead to impaired fasting glucose, hypertriglyceridemia, low HDL cholesterol levels, high levels of apolipoprotein B and blood pressure increases, among other conditions, which are integrated in the metabolic syndrome (MS), although not always are all of them present simultaneously. Low levels of formal education are significantly associated with central obesity, especially in women, and MS. It is necessary to raise public awareness on obesity control and encourage changes in lifestyle to reduce the risk of T2DM and CVD.

Keywords : Central obesity; Metabolic syndrome; Insulin resistance; Components of the metabolic syndrome; Pathophysiology; Diabetes mellitus type 2; Cardiovascular disease.

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