Abstract

SALAZAR GARCIA, Marcela et al. Cystatin C as a routine test to evaluate kidney function in pediatric patients. Acta bioquím. clín. latinoam. [online]. 2015, vol.49, n.2, pp.193-200. ISSN 0325-2957.

Numerous studies have shown that plasma levels of cystatin C are more accurate than creatinine estimating the Glomerular Filtration Rate (eGFR), however they are not used as a routine test in the diagnosis of pediatric renal pathologies. The aim of this study was to determine GFR for cystatin C in Mexican pediatric patients exposed to risk factors of Acute Kidney Disease (AKD) compared to children without risk factors for AKD and corroborate the advantages of using this marker in the early diagnosis of kidney diseases in relation to creatinine. A total of 106 samples were analyzed to estimate the GFR. Creatinine and cystatin C concentration were quantified by substituting the values in the MDRD v-4 and Filler and Lepage formulas respectively. The concentrations of both creatinine and cystatin between the study groups were compared by Mann Whitney. Likewise, the correlation between these two metabolites divided by presence or absence of risk factors present in renal disease was assessed. A correlation between creatinine and serum cystatin C concentrations was observed in both groups of patients without risk factors of AKD (r=0.936, p<0.001) and in those who presented risk factors of AKD (r=0.952 , p<0.001). The risk factor group showed higher concentrations of cystatin and creatinine as well as eTFG for both metabolites. Cystatin C shows a good correlation with creatinine. Furthermore, altered cystatin identified a greater number of patients with risk factors of AKD and it is proposed as a screening test in pediatric patients.

Keywords : Cystatin C in children; Acute kidney disease; Serum creatinine; Glomerular filtration.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )