Abstract

NIETO-CARDENAS, Olga Alicia; ZARATE, Mélida del Pilar  and  LANDAZURI, Patricia. Exercise training and functional networks of physiological and biochemical variables in hipertensión. Acta bioquím. clín. latinoam. [online]. 2015, vol.49, n.4, pp.383-392. ISSN 0325-2957.

The aim of this study was to evaluate the effect of exercise on several biomarkers. For the first time, the changes caused by exercise training in physiological relationships were investigated using structural analysis. Hypertensive patients were divided into exercise group (EXG) and not exercise group (NEXG)). Lipid profile, HDL subpopulations, apoAI, MMP-2 and MMP-9 were assessed at baseline and after 8 weeks of intervention. Data show a significant exercise-related variation in HDL3 (p=0.0236) and SBP (p=0.0448). The results showed that, before exercise, biochemical and physiological variables were compartmentalized and independent; while after exercise these  variables were able to establish relationships. This study demonstrates that an exercise training program significantly reduces systemic BP and HDL3 and increases HDL2 and MMP-2. But the main finding is that physical exercise is effective in generating or restoring a network of relationships between physiological variables loke BP and biochemical variables like MMP-2, MMP9, apoA-I, HDL2 and HDL3.

Keywords : Exercise; Hypertension; Metalloproteinases; Extracellular matrix; HDL subpopulations.

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