Abstract

BENHAIM, Marcela Estela et al. Neurobiología, neurociencia e inmunología en el espectro autista. Acta bioquím. clín. latinoam. [online]. 2020, vol.54, n.2, pp.173-182. ISSN 0325-2957.

Thirty patients with autism spectrum disorder (ASD) who attend specialized centers in Buenos Aires and its suburbs were carefully studied. All of them underwent a psycho-neuro-cognitive study. The psychologists used the IDEA (Autism Spectrum Inventory) scale which is focused on twelve characteristically significant dimensions with four typical levels in each of those dimensions studied. Their parents or guardians completed a survey with epidemiological data and possible factors of allergies and/or intolerance presence were investigated. This survey was also distributed among other families with children with ASD condition so that the epidemiological results were taken from a larger number of cases. Anti-endomysial and anti-transglutaminase antibodies usually related to celiac disease, total IgE related to allergic processes, homocysteine measures in serum or urine, cortisol measured in serum or urine and brain-derived neurotrophic factor (BNDF) were dosed in all the cases. The aim was to establish possible causal associations between the studied parameters and the manifestations of the autism spectrum disorder.

Keywords : Autism spectrum disorders; Allergies; Gluten intolerance; Immunological markers; Neurotrophic factor derived from the brain.

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