Abstract

SALDANA OREJON, Italo Moisés  and  BENITES RICRA, Miguel Ángel. Medición directa versus el valor estimado del colesterol de LDL por las ecuaciones de Friedewald, Friedewald modificada y de regresión. Acta bioquím. clín. latinoam. [online]. 2020, vol.54, n.3, pp.267-277. ISSN 0325-2957.

Several studies show the association between high LDL cholesterol (LDLc) levels and the risk of developing atherosclerotic cardiovascular disease. In order to compare the LDLc values obtained by direct measurement and the values estimated by the traditional, modified and regression Friedewald equations, the LDLc of 4,621 patients was assessed by means of the direct test in the ADVIA 1800 autoanalyzer.These results were grouped into the states of normolipemia, hypercholesterolemia, mixed hyperlipemia and hypertriglyceridemia, establishing differences in estimation with the aforementioned formulas in the total sample and in clinical decision levels for LDLc. The three formulas showed a significant correlation with the direct method in the entire sample; however, when the triglyceride levels of the samples exceeded 200 mg/dL, the difference between Friedewald’s formula and the direct method was -11.94% reaching -19,13% for the triglyceride level greater than 400 mg/dL, while the modified Friedewald and regression equations were affected to a lesser extent by the triglyceride level. Regression and modified Friedewald formulas are constituted as reasonable alternatives to estimate LDLc and have good agreement with the direct method, even at high cholesterol and triglyceride levels.

Keywords : LDL cholesterol; Atherosclerotic cardiovascular disease; Clinical decision levels; LDL cholesterol calculation.

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