Abstract

SOLOAGA, Rolando et al. Estudio colaborativo sobre la utilidad del panel Meningitis/Encephalitis FilmArray (Biofire) en el diagnóstico de pacientes con sospecha de meningitis o encefalitis. Acta bioquím. clín. latinoam. [online]. 2021, vol.55, n.1, pp.55-60. ISSN 0325-2957.

The initial treatment for patients with suspected acute bacterial meningitis depends on a rapid diagnostic evaluation and adequate antimicrobial therapy. The Meningitis/Encephalitis FilmArray panel (ME) (BioFire Diagnostics, Salt Lake City, USA) uses multiplex PCR analysis and includes 14 microorganisms; the results are obtained directly from the CSF in 1 h. The objectives of this study were: a) to determine the performance of ME and b) to establish the impact of the result obtained on the antimicrobial treatment of patients with meningoencephalitis. A number of 112 patients and 26 episodes of meningitis were included. Of the total positive results for bacteria and fungi with the panel, 4/13 were not isolated from cultures and corresponded to patients with antimicrobial treatment. Of the 26 episodes, the results led to therapeutic changes in 21 cases. ME is a quick and useful tool to adapt antimicrobial treatment in patients with meningoencephalitis.

Keywords : Meningitis; Microbiological diagnosis; FilmArray; Multiplex PCR.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )