Abstract

GAZZELI, Luciana Soledad; GALVEZ, Silvia Mabel  and  PRENER, Paola Claudia. Interferencia positiva de las paraproteínas en la determinación de bilirrubina total y su rol en el diagnóstico de gammapatías monoclonales. Acta bioquím. clín. latinoam. [online]. 2024, vol.58, n.1, pp.7-7. ISSN 0325-2957.

Paraprotein interference in clinical biochemistry has been widely reported around the world. Methodological strategies have been proposed to avoid reporting erroneous data due to interferences (i.e. manual check, alert system); however, few cases have suggested its use as a diagnostic tool for unsuspected pathologies. Based on the joint work of two hospitals from Buenos Aires Province, the following has been described: i) the presence of positive interference of paraproteins in the assessment of total bilirubin with Wiener chemistry and autoanalizers, and ii) its contribution, in less than six months, to the diagnosis of four gammophaties previously unsuspected (three monoclonal ones). Sharing the occurrence of this interference in our country is recommended. An interference identification workflow is also propose, as well as a set of biochemical assays to evaluate the occurrence of unsuspected gammophaties.

Keywords : Pseudohyperbilirubinemia; Monoclonal gammopathies; Analytical interference; Paraproteins; Monoclonal proteins.

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