Abstract

LOPEZ, Carolina Murúa et al. First evidence of systemic infection and specific cytotoxic T lymphocyte immune response evoked by oral infection with recombinant Salmonella entérica serovar Albany-Ovalbumin in C57BL/6 mice. Rev. argent. microbiol. [online]. 2022, vol.54, n.4, pp.121-130.  Epub Dec 01, 2022. ISSN 0325-7541.  http://dx.doi.org/10.1016/j.ram.2022.05.008.

Our group isolated Salmonella enterica serovar Albany from food and feces of wildcaptive carnivores in a zoo from northwestern Mexico. This serovar was also associated with thedeath of an ocelot (Leopardus pardalis) in the same zoo. Another group associated S. Albanywith the death of a human patient. It is due to this zoonotic potential that the in vivo study of thehost-S. Albany relationship is critical. The recombinant S. Albany-Ovalbumin (rSAO) strain wasused to analyze a murine oral infection and its specific cytotoxic T lymphocyte (CTL) response.Our results have shown for the first time that rSAO establishes a systemic infection and evokesepitope-specific lysis with a Th1-like cytokine profile in vivo.

Keywords : Cytotoxic Tlymphocytes; Salmonella entericaserovar Albany; Recombinant bacterium.

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