Abstract

LOPARDO, Horacio A. et al. Beta-lactam antibiotics and viridans group streptococci. Rev. argent. microbiol. [online]. 2022, vol.54, n.4, pp.131-140.  Epub Dec 01, 2022. ISSN 0325-7541.  http://dx.doi.org/10.1016/j.ram.2022.06.004.

The aim of this review is to present an update on the susceptibility of viridans groupstreptococci (VGS) to -lactam antimicrobials, with emphasis on the Argentinean scenario. VGSare a heterogeneous group including five groups of species, each one exhibiting peculiar sus-ceptibility patterns to penicillin (PEN). Species of the Streptococcus mitis group are frequentlynonsusceptible to PEN. PEN resistance is associated with changes in PEN-binding proteins. InArgentina, one to two thirds of VGS are nonsusceptible to PEN. Third generation cephalosporinsand carbapenems are currently more effective in vitro than PEN against VGS. Mortality was asso-ciated to nonsusceptibility to PEN in at least two studies involving patients with bacteremiacaused by VGS. Treatment of endocarditis due to VGS should be adjusted/to the PEN suscepti-bility of the isolates. Vancomycin may be an alternative choice for treating endocarditis causedby PEN-resistant isolates (MIC 4 g/ml).

Keywords : Viridans groupstreptococci;Lactams; Resistance; Penicillin bindingproteins ;Endocarditis.

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