Abstract

GRAMUNDI, Ivan et al. Characterization of third generation cephalosporin-resistant Escherichia coli clinical isolates from Ushuaia, Argentina. Rev. argent. microbiol. [online]. 2023, vol.55, n.1, pp.101-110.  Epub Mar 01, 2023. ISSN 0325-7541.  http://dx.doi.org/10.1016/j.ram.2022.06.002.

Escherichia coli is one of the main human pathogens causing different hospital- and community-acquired infections. During the period from January 2013 to March 2015, 1.96% (32/1632) of E. coli isolates recovered at the Hospital Regional de Ushuaia, Tierra del Fuego province, were resistant to third-generation cephalosporins (TGCs). These isolates were resistant to cefotaxime (91%) and/or ceftazidime (28%). No resistance to carbapenems was detected. Twenty-six isolates were positive for blaCTX-M gene, grouped as CTX-M-1/15 (54%); CTX-M-9/14 (25%); CTX-M-2 (17%); and CTX-M-1/15 plus CTX-M-9/14 (4%). Five TGC-resistant strains were positive for blaCMY gene, while one strain harbored TEM-19 ESBL. Twelve isolates were identified as ST131 E. coli hyperepidemic clone, and one as ST69. Genome sequence analysis of seven blaCTX-M-15 E. coli selected isolates confirm the circulation of ST131, ST617 and ST405 international high-risk clones in the city of Ushuaia.

Keywords : Extended-spectrum beta-lactamase; Escherichia coli; Third-generation cephalosporin; ST131.

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