Abstract

MACIAS PAZ, Ignacio Uriel et al. Candida albicans the main opportunistic pathogenic fungus in humans. Rev. argent. microbiol. [online]. 2023, vol.55, n.2, pp.12-12. ISSN 0325-7541.  http://dx.doi.org/10.1016/j.ram.2022.08.003.

Candida albicans is a commensal of the mammalian microbiome and the primarypathogenic fungus of humans. It becomes a severe health problem in immunocompromisedpatients and can cause a wide variety of mucosal and systemic infections. The interactionbetween C. albicans and host cells is characterized by the expression of virulence factors suchas adhesins and invasins, the secretion of hydrolytic enzymes, a transition from yeast to fil-amentous hyphae form, and the ability to form biofilms; these features collectively result in cell adhesion, invasion, and damage. This review describes complex commensal interactions of C. albicans with host cells and the cellular events that it triggers in a pathogenic environment. We also review the host immune response induced by C. albicans antigens and the mechanisms developed by this fungus to avoid the action of antifungal agents.

Keywords : Candida albicans; Candidiasis;Virulence factors.

        · abstract in Spanish     · text in English     · English ( pdf )