Abstract

HUANG, K. et al. Enantioselective extraction of ketoprofen enantiomers using ester alcohol R, R-di-tartarates or S, S-di-tartarates as chiral selector. Lat. Am. appl. res. [online]. 2006, vol.36, n.3, pp.187-191. ISSN 0327-0793.

Distribution behavior of ketoprofen enantiomers was examined in a two-phase system containing R, R-di-tartarates or S, S-di-tartarates. The influences of different alkyl chain of R, R-di-tartarates or S, S-di-tartarates, concentrations of R, R-di-tartarate, organic solvent and content of methanol on partition coefficient and separation factor were investigated, respectively. The experimental results show that R, R-di-tartarates studied all form more stable diastereomeric complexes with ketoprofen S-enantiomer than with R-enantiomer. The partition coefficients and enantioselectivity generally increase with the addition of length of alkyl chain of alcohol. The concentration of chiral selector and methanol also have bigger influences on enantioselectivity.

Keywords : Enantioselective Extraction; Ketoprofen Enantiomers; Partition Coefficient; Separation Factor; Chiral Selector.

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