Abstract

PENG, X.; HUANG, K.; ZHANG, S.  and  LIU, J.. Assembly and release of diclofenac acid-pillared hydrotalcites. Lat. Am. appl. res. [online]. 2010, vol.40, n.3, pp.227-231. ISSN 0327-0793.

A pharmaceutically active material diclofenac was intercalated into a layered double hydroxide by co-precipitation method, release studies suggest that the result diclofenac acid-pillared hydrotalcites (Dic-LDHs) have significant sustained release effect. The complex materials were characterrized using XRD, FTIR, DSC-TG, EA and ICP. The result show that the interlayer distance of the Dic-LDHs is expanded to 1.83nm and the thermal stability of material increases after the intercalation of diclofenac.

Keywords : Diclofenac Acid; Hydrotalcites; Release; Assembly.