Abstract

CABRERA FISCHER, E.I. et al. Description of an animal model of acute cardiac failure: In vivo experiments in sheep. Lat. Am. appl. res. [online]. 2011, vol.41, n.3, pp.233-239. ISSN 0327-0793.

The purposes of this work were to, a) describe an acute animal model of severe cardiac failure induced by high doses of halothane, b) analyze the effects of these overdoses of halothane on arterial wall dynamics and c) characterize the cardiovascular effects of halothane through the autonomic nervous system. Measurements were performed in six sheep before and after halothane administration (4%). A significative decrease was observed in mean aortic flow (P<0.05) and diameter (P<0.01) in heart failure with respect to control state (from 2.64±0.95 L.min^-1 and 17.32±1.86 mm to 1.69±0.58 L.min^-1 and 15.33±1.71 mm; respectively). A significantly decrease was observed in mean (P<0.005), systolic (P<0.01) and diastolic (P<0.005) aortic pressure in heart failure (from 85.90±19.49 mmHg, 93.52±18.07 mmHg and 78.86±20.12 mmHg to 49.12±21.77 mmHg, 55.54±20.71 mmHg and 43.48±21.21 mmHg; respectively). Heart rate in control group (127.73±11.20 bpm) was significantly (P<0.05) higher than that observed in heart failure (107.15±13.53 bpm).

Keywords : Cardiac Failure; Halothane; Left Ventricular Dysfunction.

        · text in English     · English ( pdf )