Abstract

TAUIL, Ricardo Martín Neme et al. Archaeoproteomics as a complement of paleopathological studies in human skeletal remains of Cueva de Plaza, Chubut, Argentina: scope and limitations. Rev Arg Antrop Biol [online]. 2023, vol.25, n.1, e062.  Epub Jan 01, 2023. ISSN 1514-7991.  http://dx.doi.org/10.24215/18536387e062.

In this work a proteomic analysis by mass spectrometry of a human phalanx with a macroscopic alteration found in Cueva de Plaza archaeological site (Chubut, Argentina) is proposed, representing the first time that such analysis has been carried out on archaeological materials in Argentina. Two methods of protein extraction from archaeological bone remains are presented to be analyzed with a mass spectrometer. Both methods yielded non-exclusive, partially redundant and complementary results. Collagens, fibronectin, proteins from cartilage, bone, muscle and blood and, to a lesser extent, proteins associated with the immune system and other metabolic pathways were identified. These proteins are consistent with the existence of a healing trauma process in the analyzed bone element.

Keywords : proteomics; bioarchaeology; paleopathology; Patagonia.

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