Abstract

BAGNASCO, Mariana Suárez. Orthostatic hypotension and cognitive impairment/dementia in adults. Salud(i)Ciencia [online]. 2019, vol.23, n.6, pp.524-528.  Epub Oct 08, 2019. ISSN 1667-8682.  http://dx.doi.org/www.dx.doi.org/10.21840/siic/159549.

A narrative review was made on orthostatic hypotension and cognitive impairment / dementia. The databases PubMed and PsycInfo were used. The original studies published in English between 2013 and 2018 were identified. The keywords used during the search were the following: "orthostatic hypotension", "adults" and "cognitive" / "cognitive impairment" / "dementia". We found 20 original studies that explore the relationship between orthostatic hypotension and cognitive / dementia. Most of the studies reviewed provide evidence in favor of the existence of an association between orthostatic hypotension and cognitive impairment / dementia in adults: 8 of 11 papers provide evidence in favor of the existence of an association between orthostatic hypotension and cognitive impairment, 6 of 7 papers provide evidence in favor of the existence of an association between orthostatic hypotension and dementia, and 2 of 2 papers provide evidence in favor of the existence of an association between orthostatic hypotension and mild cognitive impairment. The authors suggest that both brain hypoperfusion and cellular damage could explain, at least partially, the link between orthostatic hypotension and the cognitive disorders described in the literature. Future studies may identify mechanisms that explain the association between orthostatic hypotension and cognitive impairment / orthostatic hypotension and dementia in adults to reduce the risk of cognitive impairment / dementia or at least slow down its progression.

Keywords : orthostatic hypotension; cognitive impairment; dementia; blood pressure.

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