Abstract

ROCHA,, Gloria Gordillo et al. Natural therapies for the reduction of complications in patients with type 2 diabetes and COVID-19. Salud(i)Ciencia [online]. 2021, vol.24, n.5, pp.232-236.  Epub Nov 05, 2021. ISSN 1667-8682.  http://dx.doi.org/10.21840/siic/165762.

Background: In December 2019, a series of cases occurred in Wuhan (China), caused by a new coronavirus. On March 11, 2020, the WHO declared the COVID-19 disease, caused by SARS-CoV-2, as a pandemic. In Peru, the first person infected with SARS-CoV-2 was confirmed on March 6, 2020. The number of infected has been constantly increasing to this day. Purpose: It is relevant to the current pandemic, understanding the mechanism of infection of SARS-CoV-2 in diabetic patients and in this way to be able to provide natural alternatives to reduce the complications that these patients can carry out until death. Methodology: An information search was carried out between April 6 and August 25 of 2020 in databases and indexed journals, whose articles have been published between 2011 and 2020. Results: It was found regarding inhibitors of dipeptidil peptidase (DPP-4) evaluated in in vitro tests, that the Berberis aristata species has a metabolite called “berberine”, which has the highest inhibitory capacity among the mentioned species, and, with respect to furin inhibition, among the in vitro tests, catechin has significant inhibitory capacity, it also has DPP-4 inhibitory activity. Conclusion: There is a great variety of medicinal plants with inhibitory properties for DPP-4 and some for furin. These properties are beneficial in patients with type 2 diabetes, since they reduce the activity of these proteases and, consequently, the complications in SARS-CoV-2 infection.

Keywords : diabetes mellitus type 2; COVID-19; DPP-4; furine.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )