Abstract

BRESCIA,, Sebastián; RAMOS,, Ronald; JEMAR,, Guillermo Nicolás  and  RUIZ,, Adolfo. Autologous platelet rich plasma for the treatment of diabetic foot ulcer. Salud(i)Ciencia [online]. 2022, vol.25, n.3, pp.145-153.  Epub Jan 20, 2023. ISSN 1667-8682.

Background: Diabetic foot ulcer is one of the frequent complications of diabetes. 15% to 25% develop ulcers at some point in their lives. The existing evidence on the efficacy of topical autologous platelet-rich plasma (PRP) for the treatment of diabetic foot ulcers was assessed. Method: A search for randomized controlled clinical trials comparing autologous topical PRP vs standard care and placebo was carried out in PubMed, Cochrane, Lilacs, and Clinical Trials databases. For dichotomous outcomes, relative risk analysis, 95% CI, and the Mantel-Haenszel method were used; for continuous outcomes, the mean difference and inverse variance method were calculated. Results: The result of the search was 153 studies, 28 duplicates were excluded, 59 by title and abstract, and 52 by reading the article. 14 studies were included in the review, 8 for qualitative review and 6 for quantitative. Six studies with a complete ulcer-healing outcome at the end of the intervention were evaluated, out of a total of 415 participants (relative risk 1.24 CI [1.11, 1.40]). The outcome epithelialized area at the end of the intervention, measured in cm², was not reported. A single study measured quality of life and pain. Conclusion: There is evidence of the beneficial effect of topical autologous PRP for the healing of diabetic foot ulcers, however, studies of higher methodological quality, greater production of clinical trials in Latin America, and assessment of the quality of life and pain are needed.

Keywords : autologous platelet rich plasma; diabetic foot ulcer; gel platelet rich plasma; quality of life; diabetes.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )