Abstract

SANCHEZ LEGAZA, Elena  and  POZO SANCHEZ, Alejandro. Complicated oropharyngeal actinomycosis secondary to pharmacotherapy. Salud(i)Ciencia [online]. 2023, vol.25, n.6, pp.345-349.  Epub Nov 05, 2023. ISSN 1667-8682.  http://dx.doi.org/10.21840/siic/173309.

Anti-tumor necrosis factor (TNF)-α treatment is an effective therapeutic option in intestinal inflammatory chronic disease in cases of ineffectiveness of other drugs, but it promotes the development of opportunistic infections in their severe forms, due to the profound suppression of T-cell mediated inmmunity it produces. Among the most frequent are bacterial granulomatous infections, such as mycobacteria (especially tuberculosis) and fungal infections.

Actinomycosis is a rare suppurative granulomatous chronic opportunistic infection, which in states of immunosuppression, such as that it´s caused after treatment with TNF blockers, it is complicated by more severe clinical pictures.

We present the clinical case, it is not previously described, of a cervico-facial actinomycosis complicated with pneumonia, and it is secondary to treatment with adalimumab in a patient with Crohn's disease.

Keywords : actinomycosis; cervicofacial infection; anti-TNF-α; adalimumab; Crohn´s disease; treatment; intestinal inflammatory disease.

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