Abstract

TOSO, R.E; TORIBIO, M.S; MENGELLE, P  and  BOERIS, M.A. Antiulcerogenic and antispasmodic effects of plants from La Pampa, Argentina. InVet [online]. 2007, vol.9, n.1, pp.145-151. ISSN 1668-3498.

The objective of the research was the analysis of the antiulcerogenic and antispasmodic effects of Marrubium vulgare (MV), Acmella decumbens (AD), Lippia turbinata (LT), Tribulus terrestres and Ruta chalepensis (RC) hidroalcoholic extracts. Antiulcerogenic activity was studied in mices for their ability to inhibit the gastric lesions induced on cold restraint stress. Gastrointestinal motility was evaluated with activated charcoal as intestinal transit indicator. Atropine and ranitidine were used like gastroprotectives. Atropine was used for decrease gastrointestinal motility. We proved that all plant extracts and atropine have gastroprotective activity (p< 0.01). Ranitidine did not prevent ulcers in mice. The extracts MV and AD also significantly reduced the intestinal transit in charcoal meal test when compared with atropine. LT, TT and RC extracts moderate but significantly inhibited gastrointestinal transit compared with control group (p< 0.01). These results further suggest that all extracts were found to possess antiulcerogenic and inhibitory activity on gastrointestinal motility, which might also be due to antispasmolitic activity.

Keywords : Gastroprotective; Antispasmodic; Plant extracts.

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