Abstract

SARRADELL, J. et al. Oval cells in the liver of rats with severe surgical lesions. InVet [online]. 2010, vol.12, n.1, pp.19-24. ISSN 1668-3498.

Surgical experiences to histologically visualize the presentation and intervention of stem cells in the hepatic cellular healing of rats were drawn. In one experience the hepatic tissue was slightly injured and in other group severe lesion was done. In the fi rst group there was scaring. In the second group there was massive proliferation of biliary ducts of sinuous tract generating abundant satellital extensions when the lesion was severe. In relation to these structures, a great quantity of cells being morphologically compatible with hepatic oval cells (oval nucleus and cytoplasm and large nucleus to cytoplasm ratio) were observed. In conclusion the hepatic healing after a lesser damage is made by proliferation of differentiated cells and extreme damages begin healing by non-differentiated stem cells from biliary ducts generating hepatocytes and ductal cells.

Keywords : Liver; Oval cells; Surgical lesions; Histopathology.

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