Abstract

VELEZ, CL et al. Immunolocalization of integrin A5B1, laminin and type v collagen in porcine placenta in different gestational stages.. InVet [online]. 2019, vol.21, n.2, pp.1-12. ISSN 1668-3498.

Adhesion molecules are essential for anchoring and adhesion during swine placentation in both the maternal and the fetal epithelia. The aim of this work was to determine the expression of a5ß1 integrin and its receptors, laminin and collagen type V, in swine placentas at different gestation intervals: 30, 60, 70 and 114 days of gestation (dg; n = 23). The expression of these molecules was determined by immunohistochemistry. Here we found that the a5ß1 integrin was expressed at high levels in endometrial connective tissue and around blood vessels of the maternal and fetal placenta. Laminin was expressed in the swine fetal-maternal interface, at 30, 60 and 114 dg in a mild manner. On the other hand, the expression was strong in endometrial stroma, endometrial glands, blood vessels and basal membrane of the villi throughout pregnancy. Collagen type V was strongly expressed in the mesenchyme villi of the maternal placenta and around the fetal and maternal placenta vessels. Based on our results, we postulate that a5ß1 integrin, and its receptors, could play a crucial role in the development and maintenance of placental architecture and angiogenesis.

Keywords : Integrin; Laminin; Collagen; Porcine gestation.

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