Abstract

BURNA, A.N et al. Efecto de la diminacina en hámsteres inoculados con Leishmania chagasi. Rev. vet. [online]. 2013, vol.24, n.2, pp.133-137. ISSN 1669-6840.

Leishmaniosis is a disease caused by protozoa of the genus Leishmania, which is transmitted to human beings by the bite of infected insects. Diminazine is a drug with proven in vitro growth inhibition activity of Leishmania donovani and has also been used for the treatment against trypanosomosis and other parasitic diseases. The aim of this study was to determine the effect of diminazine in vivo as an antileishmanial drug in hamsters for the possible extrapolation and thus potential use as a therapeutic alternative in dogs. Twenty six hamsters were divided into four groups, two groups of 6 animals each, and two groups of 7 each. Some animals were inoculated IM with macerated spleen from a dog naturally infected with Leishmania chagasi. The diminazine treated group and the control animals inoculated with the protozoa presented amastigotes of L. chagasi in smears and in histopathological sections. Diminazine treated animals remained in better health state unlike the control group inoculated with L. chagasi. Results suggest that diminazine would have a benefcial effect in infected dogs.

Keywords : Diminazine; Leishmania chagasi; Inoculation; Hamster.

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