Abstract

FERRE, D.M. et al. Inhibición de butirilcolinesterasa en dos perros intoxicados y confirmación analítica de carbofuran como agente causal. Rev. vet. [online]. 2015, vol.26, n.1, pp.43-48. ISSN 1669-6840.

Domestic and wild animals' death due to pesticide poisoning is of worldwide concern and in most of the cases is a consequence of the exposure to insecticides. Organophosphorus and carbamates anticholinesterase compounds are frequently implicated. Pet dogs and cats are considered good resources to warn about the presence of poisons in the environment and the potential risks they represent to human beings. The aim of this work was to perform complementary laboratory studies in two dogs with signs of intoxication in order to identify the possible cause. Diagnostic approach through plasmatic butyril cholinesterase (BChE) and HPLC determination are presented. BChE activity of each canine was 227 IU/L thus meaning an inhibition of more than 90% of the basal activity of the enzyme. The presence of carbofuran in plasma and gastric contents as the cause of poisoning was confirmed. Cholinesterase inhibitors pesticides, especially carbamates, are the leading cause of poisoning in animals. The determination of BChE activity in intoxicated animals as a diagnostic tool is emphasized. Also, strong regulations on the commercialization of pesticides with low LD50 such as carbofuran as well as the report of both intentional and accidental intoxications are mandatory in order to avoid further cases in animals and possible cases in humans

Keywords : dog; intoxication; carbofuran; cholinesterase; HPLC.

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