Abstract

RUIZ, S. et al. Efecto de la cafeína sobre parámetros sanguíneos de ratones con diabetes mellitus inducida por streptozotocina. Rev. vet. [online]. 2015, vol.26, n.2, pp.120-123. ISSN 1669-6840.

Diabetes mellitus is a metabolic disorder affecting various organs and tissues, being its main feature the high blood glucose level that leads to a series of alterations that makes animals ´ everyday life challenging. It has been reported that caffeine modifies the metabolism of glucose, lipids and proteins. The aim of this study was to determine the effect of caffeine on hyperglycemia, trigliceridemia and cholesterolemia in mice with experimental diabetes mellitus. Female mice were used with an average weight of 35 g, divided into three groups: controls, diabetic (D) and diabetics treated with caffeine (C). Diabetes was induced by the administration of streptozotocin (40 mg/kg for 5 days). On days 0, 20 and 35 blood plasma was analyzed to determine glucose, triglycerides and cholesterol. Caffeine was administered for 15 days in the drinking water at a concentration of 0.7 mg/ml. Data were statistically analyzed by ANOVA (p<0.05). Results reveal a significant difference in the values of glucose, triglycerides and cholesterol between D and C groups. It was evident that group C had lower levels for all the parameters. It can be concluded that caffeine decreases blood levels of glucose, cholesterol and triglycerides and may well improve their metabolism in patients with diabetes

Keywords : mice; streptozotocin-induced diabetes mellitus; caffeine; reduction of glycemia; triglyceridemia; cholesterolemia.

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