Abstract

MARTIN, U.O. et al. Hacia un control inmunológico de la toxocariasis: inmunoprotección en canes con antígenos de Toxocara canis. Rev. vet. [online]. 2016, vol.27, n.1, pp.28-31. ISSN 1669-6840.

In dogs and humans toxocariasis is controlled with the use of antiparasitic drugs. Its continued use generates resistance in the parasite. The dog is crucial in the environmental contamination with Toxocara canis eggs and subsequent accidental human transmission. Interrupting the epidemiological chain of transmission is fundamental. In this preliminary study, immunoprotection is investigated in dogs with T. canis antigens. For this purpose, five dogs were inoculated: two (one female and one male) with excretory-secretory antigens and two (females) with hidden antigens. A male was intended as a control. At 15 days after the second dose, all animals were challenged with 500 T. canis larvated eggs. At 25 days dogs were dewormed, and parasite loads were registered as indicator of effectiveness of the inoculation. All the animals showed eggs at day 25 post challenge and the subsequent negative result after 20 days in immunized dogs. In the control dog the number of eggs was higher on day 25 post challenge compared to experimental animals, being even higher in the following days. These initial results encourage studies for the selection of antigens and immune protection as preliminary tests in order to develop a vaccination protocol for dogs. No previous references regarding these types of assays were found in the scientific literature.

Keywords : dog; toxocariasis; antigens; immunoprotection.

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