Abstract

ESCALANTE, A.M.; BURNA, A.N.  and  PEREZ-GIANESELLI, M.. Acción de la diminacina asociada al alopurinol y levamisol en hámsteres inoculados con Leishmania chagasi. Rev. vet. [online]. 2016, vol.27, n.2, pp.113-116. ISSN 1669-6840.

Leishmaniasis affects different species of domestic and wild animals, being the canines its main reservoir. In Corrientes (Argentina), a high incidence of canine visceral leishmaniasis is registered, with risk for the public health. The aim of this study was to demonstrate the in vivo effect of diminazine, associated with allopurinol and levamisole, as antileishmanial hamster treatment, in order to use these treatment as a therapeutic alternative for the control and possible eradication of leishmaniasis in dogs. Tree groups were formed with 26 hamsters (Mesocricetus auratus) two months old, both sexes, 60 g weight, which were divided into four lots, two batches of 6 individuals each, and two batches of 7 individuals each. Animals from lots 1 and 3 were inoculated intraperitoneally (1 ml/animal) with a macerated spleen removed from a dog naturally infected with Leishmania chagasi. Lot 3 group 1 animals were treated with diminazine; group 2 lot 3 animals were treated with allopurinol and diminazine, and group 3 lot 3 were treated with diminazine, allopurinol and levamisole. Starting from 70 days of the beginning of inoculations, euthanasias were carried out on two animals from each batch and group every 30 days, so that the animals with 30, 60 and 90 days of treatment could be investigated. Medicated-infected rodents showed fewer symptoms and better overall welfare, as evidenced by their normal state of the haircoat, good body condition, maintaining the eating habits and behavior, in contrast to the animals inoculated with L. chagasi without treatment. It is conclude that the isolated use of diminazine (leishmanicidal) produced the same protective effect (diminishing the symptomatology caused by L. chagasi) that when being associated with allopurinol (leishmaniostatic) and levamisol (immunomodulator), although none of the rehearsed treatments obtained the parasitological cure, since the presence of the parasites persisted.

Keywords : hamster; leishmaniasis; diminazine; allopurinol; levamisole.

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