Abstract

MENDOZA, C. et al. Acción protectora del ácido kaurénico en el estrés oxidativo hepático. Rev. vet. [online]. 2017, vol.28, n.1, pp.27-30. ISSN 1669-6840.

The "frailejón" is the main representative plant of the flora of the Andean Highlands of Venezuela, Colombia and Ecuador. It has been reported that kaurenic acid, a diterpenoid present in the plant, has protective effect against oxidative stress. The aim of this study was to determine the antioxidant effect of kaurenic acid and to establish its protective effect against the generation of experimental fatty liver caused by ethionine. Twenty four female NMRI mice were used. The experimental group was administered i.p. 20 mg/kg of kaurenic acid for 15 days while control group only received vehicle. Thirteen days after kaurenic acid administration, fatty liver was induced in both groups by administration of ethionine i.p. (7.5 mg/20 g) and fasting for 48 hours. Triglycerides, proteins, malondialdehyde and conjugated dienes were determined in liver homogenate, as well as the activity of superoxide dismutase and glutathione peroxidase. Results were analyzed using the "t" Student (p<0.05) test. Gathered data suggest that kaurenic acid acts as an antioxidant and reduces the genesis of lipid peroxidation.

Keywords : mouse; oxidative stress; hepatic lipidosis; kaurenic acid; antioxidant.

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