Abstract

PRADOS, A.P. et al. Farmacocinética de la cefalexina administrada por vía oral conjuntamente con enalapril en caninos adultos. Rev. vet. [online]. 2017, vol.28, n.2, pp.99-102. ISSN 1669-6840.

The purpose of the present study was to describe oral cephalexin pharmacokinetics in healthy dogs and to investigate if previous administration of enalapril affects its disposition. Six mixed breed dogs were included in this study. Each dog received oral 25 mg/kg cephalexin (group 1) or cephalexin 20 minutes after oral 0.5 mg/kg enalapril (group 2), with a 2 week wash out period, in a crossover design (3x3). Cephalexin plasma concentrations were determined by microbiological assay. T>MIC was over 60% of dosing interval for both groups. Pharmacokinetic parameters were compared performing Wilcoxon’s paired t test (p≤0.05). Results are reported as mean ± standard deviation. Group 1: Cmax 27.66±4.20 μg/ml, Tmax 1.41±0.58 h, T1/2 1.55 ±0.12 h, AUC0-∞ 110.8±10.98 μg·h/ml, and MRT 3.19±0.39 h. Group 2: Cmax 26.51±6.04 μg/ml, Tmax 1.58±0.58 h, T_1/2 1.62±0.22 h, AUC_0-∞ 110.6±17.64 μg·h/ml, and MRT 3.46±0.55 h. No statistical differences were found in cephalexin pharmacokinetic parameters between experiences. Consequently, enalapril, when co-administered orally with cephalexin, doesn’t modify the pharmacokinetic of the antibiotic

Keywords : dog; cephalexin; enalapril; interaction.

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