Abstract

LOZINA, L. et al. Desarrollo galénico y eficacia clínica de ivermectina en sistemas semisólidos para uso oral en equinos. Rev. vet. [online]. 2018, vol.29, n.2, pp.93-97. ISSN 1669-6840.  http://dx.doi.org/10.30972/vet.2923271.

Ivermectin (IVM) is a compound insoluble in water and easily soluble in organic solvents. Its distribution in the body is good and oral absorption is variable, this condition is a limitation of its bioavailability. The solubility and release of IVM can be improved by using self-emulsifying vehicles such as sodium carboxymethylcellulose and poloxamers. Aims of this work were to develop effective, safe formulations for the control of horse gastrointestinal parasites and to evaluate their clinical efficacy. We worked with 33 horses, some were pure breed while others were half-breed Silla Argentino, with 4-5 body condition and a fair to good general condition. On day 0 stool samples were collected and treatment with the formulations under study were administered. On days 3, 30 and 60 stool samples were collected to determine the reduction in eggs per gram of feces (EPG). The initial stool test was positive for roundworms and negative for tapeworms, the EPG ranged from 20 to 1690. After deworming, no adverse effects were observed in animals, demonstrating this the safeness of excipients used in our preparations. Both formulations were effective in reducing egg count, but in different ways. We conclude that both treatments were successful, however treatment 2 proved to be a more suitable sustained release system of the active ingredient.

Keywords : horse; gastrointestinal parasites; ivermectin; oral use; efficacy.

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