Abstract

LLANO, E. G. et al. Allopurinol and domperidone in the treatment of canine visceral leishmaniosis. Rev. vet. [online]. 2020, vol.31, n.1, pp.20-27. ISSN 1669-6840.  http://dx.doi.org/10.30972/vet.3114613.

19.

In Argentina, human leishmaniosis treatment is regulated by means of the therapeutic scheme suggested by WHO and is provided by the government. The objective of this present work was to evaluate the progression of clinical signs, laboratory values and parasitic load at the beginning and during the progression of canine leishmaniasis, using a protocol that combined oral administration of allopurinol and domperidone as an alternative protocol of the standard pharmacological treatment. Ten dogs were admitted at the veterinary school hospital in Corrientes (Argentina), after clinical signs were evaluated. A comprehensive environmental and pharmacological therapeutic protocol was initiated by the combination of allopurinol and domperidone and a medical follow-up with clinical, laboratorial and parasitological parameters controls. All patients demonstrated a fast response to the treatment. The combination of allopurinol and domperidone shows favorable results, as long as adjustments are made according to clinical signs, biochemical profiles and the estimation of parasitic load. Although a higher number of cases as well as trial time are necessary, the results obtained from the protocol used in this assay, may indicate that it is an alternative that can be used in the pharmacological treatment of canine visceral leishmaniasis. Thus, it may be used as a tool for the epidemiological disease control.

Keywords : canines; visceral leishmaniasis; allopurinol and domperidone; parasite charge; clinical and laboratory signs.

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