Abstract

GOMEZ, M. V. et al. Evaluation of the serum hormonal profile with a progesterone-releasing intravaginal device in sheep. Rev. vet. [online]. 2021, vol.32, n.2, pp.206-210. ISSN 1669-6840.  http://dx.doi.org/10.30972/vet.3225744.

21.

Intravaginal devices (IVD) with 300 mg of progesterone (P4) can be reused in sheep synchronization protocols with a duration of up to 7 days. The reuse of IVD with lower hormonal concentration, as well as pharmaco-kinetic studies through non-compartmental analysis of hormonal concentrations after the insertion of 1st or 2nd use devices have not been described previously. The objective of this work was to evaluate the use and reuse of IVD with an initial concentration of 160 mg of P4. For this, 20 sheep were used that made up five groups: control (without DIV), CIDN (IVD 300 mg P41st use), CIDU (IVD 300 mg P42nd use), CRON (IVD 160 mg P41st use), and CROU (IVD 300 mg P42nd use). Hormonal serum samples were analyzed by radioimmunoassay. The maximum concentration and the mean residence time were similar between CIDN and CRON, whereas CIDU presented a maximum concentration and a mean residence time greater than CROU. Also, CROU presented sub luteal serum concentrations 48 h after placement and released 68.5% less P4 than CIDU and 72.5% less than CRON. Based on the results obtained, the reuse of IVD with a lower hormonal concentration would cause sub luteal levels that could affect fertility.

Keywords : intra-vaginal device; reuse; progesterone; sheep.

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