Abstract

CORTI, Agustina  and  GARAVAGLIA, Mario. Optical Biopsy: General description and preliminary measures by autofluorescence optical spectroscopy. An. AFA [online]. 2015, vol.26, n.4, pp.167-169. ISSN 0327-358X.

The invasive medical procedure in which a sample of human tissue is removed and sent to the pathology laboratory for analysis for diagnostic purposes is usually called "biopsy". Instead, an optical biopsy is a noninvasive diagnostic procedure that performs an analysis of the tissue with an optical system using different techniques such as laser, infrared, fluorescence, spectroscopy, microscopy, among others. The sample of tissue of the body is not removed. The tissue to be analyzed is accessed through the body surface, including the analysis of the skin itself, or by endoscope to the mucosal surface of any cavity. Its main advantages over conventional biopsy are based on avoiding the possible spread of malignant cells by the latter, and avoid the intrinsic delays of conventional biopsy, in the cases in which the rapid diagnosis of malignancy allows immediate treatment, since this technique makes in-situ analysis of biochemical changes of patient´s tissues. However, significant research work is required to correlate the results of conventional biopsy with those resulting from optical biopsy before setting up a service that only treats patients by means of optical biopsies. In this paper the technique of Fluorescence Spectroscopy Optics, as well as the results of some preliminary studies of optical biopsies through it, (especially the autofluorescence) is described, comparing the natural fluorescence of healthy tissue and pathological tissue, way of contributing towards medical diagnosis.

Keywords : Biopsy; Autofluorescence; Spectroscopy; Fluorometer.

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