Abstract

MASCARO GROSSO, H.; BUSZNIEZ, P.; CASTELLINI, H. V.  and  RIQUELME, B. D.. Effect of aqueous extracts of Phyllanthus sellowianus on the viscoelastic properties of human red blood cells: in vitro antidiabetic activity. An. AFA [online]. 2023, vol.34, n.2, pp.42-45. ISSN 0327-358X.  http://dx.doi.org/10.31527/analesafa.2023.34.2.42.

Phyllanthus sellowianus Müll (Klotzch) Arg. is a native plant used for diabetes treatment. It is currently of interest to evaluate its activity on the mechanical properties of human red blood cells to elucidate its mechanism of action as an antidiabetic. For this, aqueous extracts were prepared by various extractive techniques. Using the Erythrocyte Rheometer, the in vitro effect on the viscoelastic parameters of glycated human red blood cells, as occurs by hyperglycemia in diabetes, was evaluated. The results obtained from the treatment with the extracts show that they affect erythrocyte viscoelasticity and can reverse the glycation effects.

Keywords : Phyllanthus sellowianus; Erythrocyte viscoelasticity, Diabetes.

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